More specifically, glucosamine has been shown in several studies to directly cause increased insulin resistance, reduced liver glycogen production, and reduced glucose uptake by cells. All rights reserved. of Clinical Research, Opfermann Arzneimittel GmbH (Wiehl, Germany); Dept. If the cartilage is damaged the thread of rope becomes weak and ‘leaks’ out and thus the collagen loses its nourishment as the proteoglycans lose their grip and float away. These are what are known as matrixes within the cartilage and this is where the fluid flows. Define the term chronic how you will, but the recommended daily dose is 1500mg and there exists a study indicating that short term glucosamine use doesn't in fact cause insulin resistance (18), so there is no harm in those users who only take glucosamine for a few weeks at a time and then cycle off it (although cycling of glucosamine is not actually necessary). Res. WHAT IS GLUCOSAMINE AND HOW DOES IT WORK? The studies in Richy's analysis all focused on osteoarthritis of the knee. The second method is basically the 'supplementary method'. This can get extremely painful and can even affect the joints of bones throughout the spine, which can also become very dangerous for nerves. Thus the affect of glucosamine on cartilage metabolism helps the body to repair damaged or eroded cartilage. While there were similar findings on chondroitin, those findings were not as clear-cut. Glucosamine is a natural compound found in cartilage — the tough tissue that cushions joints.In supplement form, glucosamine is harvested from shells of shellfish or made in a lab. 5777 N Meeker Ave, Boise, ID 83713-1520 USA. "It seems to be safe, and it may help in terms of symptoms." Overall safety of glucosamine and chondroitin "can be considered excellent," writes Richy. In a new study, researchers analyze data from 15 studies of these compounds. 3. et al. These, along with chondrocytes and collagen, make up cartilage. This is because when glucosamine is available for chondrocytes, they are able to produce connective tissue faster because they can skip three chemical reactions, needing only a phosphorylation reaction to make glucosamine-6-phosphate.

10 (1993). One study even showed that glucosamine sulfate supplements, when taken for a few months, helped teenage athletes with chondromalacia patella, a softening of knee cartilage, recover and return to training. The content on our website is for informational and educational purposes only and is not intended as medical advice or to replace a relationship with a qualified healthcare professional. There are several forms of glucosamine, including glucosamine sulfate, glucosamine hydrochloride and N-acetyl glucosamine.
Besides drawing in precious fluid, chrondroiton protects cartilage, stops it from breaking down and inhibits certain ‘cartilage chewing’ enzymes. Ingestion of Glucosamine has been shown to actually stimulate GAG and PG production (1). Another problem that can arise is the onset of type II diabetes from the increased insulin resistance, which has been shown in several studies over the years (11, 12, 13, 14, 15, 16, 17). 4, 1980, Yongyudh Vajaradul, Dept. Manufactured glucosamine is derived from Chitin, a major component of shellfish shell. Without this fluid, cartilage becomes malnourished, drier, thinner and fragile. In the last few years, excellent results have been achieved with a combination of natural nutritional supplements. The reason being that during the preparation, sodium and potassium are added to glucosamine (resulting in the 83% for the HCL version), but the sulphate version has sulphur added (hence, 'sulphate') which results in a net loss of glucosamine per capsule or tablet. 3, No. At the end of the day, glucosamine supplementation is proven to help joints (20) and really should be a supplement any strength athlete; especially bodybuilders and power lifters have on their supplement shelf. Uebelhart D, Thonar EJ, Zhang J, Williams JM Department of Clinical Neurosciences and Dermatology, University Hospital of Geneva, Switzerland.

They are thought to help slow the loss of cartilage -- called joint space narrowing -- seen with osteoarthritis by stimulating production of new cartilage. It's at about this time that you may notice joints getting that little bit sorer after a hard workout, or your knees getting stiff a few hours after cardio. In the first method, a glucose molecule will be phosphorylised (have a phosphate group added) and will then undergo epimerization reactions (basically changing the configuration of the compound). and E. D'Este, M.D., Hospital 'G. Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement. Emilsson V, O'Dowd J, Nolan AL, Cawthorne MA. Crabs, shellfish and lobsters tend to be the popular choice of manufacturers. There are substantial beneficial effects on symptoms of glucosamine and chondroitin therapy compared with placebo, he adds. What Does It Do? Firstly, healthy cartilage needs three things: water for lubrication and nourishment, proteoglycans to attract and hold the water, and collagen to keep the proteoglycans in place. But after oral administration, glucosamine sulphate is split into glucosamine and a sulphate ion so like previously mentioned, the effects are identical and it doesn't matter whether you take the HCL or sulphate version. 5 (1981), E. D'Ambrosia, B. Casa, R. Bompani, G. Scali & M. Scali - Hospital "G Stuard", II Division, Parma, Italy; Pharmatherapeutica, (1981), 2, 504, Antonio Lopes Vaz, M.D.